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Study Demonstrates that Patients with Post-Traumatic Migraine Following Concussion Showed Prolonged Brain Network Impairment
[June 30, 2015]

Study Demonstrates that Patients with Post-Traumatic Migraine Following Concussion Showed Prolonged Brain Network Impairment


ElMindA Ltd. announced today that a study published by Brain Imaging and Behavior provides important new information about the assessment of patients following a concussion, particularly those with post-traumatic migraine (PTM). The study compared individuals with PTM following sport-related concussion (SRC) to those without PTM following SRC, as well as healthy individuals, utilizing Brain Network Activation (BNA™). The findings indicate that individuals with PTM following sports-related concussion exhibit reduced BNA network activity and connectivity scores, and support use of BNA in assessing PTM throughout post-concussion recovery.

PTM - which may include headache, nausea, and light and/or noise sensitivity - is linked to prolonged recovery and poor outcomes from sports-related concussion. Concussions and migraine headaches share similar pathophysiological characteristics, and therefore patients with PTM may demonstrate distinct brain network activity following concussion than those without PTM.

"To date, there has been limited understanding or examination of the electrophysiological brain activity in patients with post-traumatic migraine following concussion. This helps to expand the understanding of post-traumatic migraine throughout the stages of concussion recovery, and could potentially help provide critical information for both healthcare providers and researchers," said Ronen Gadot, CEO of ElMindA, the developer of BNA. "ElMindA is committed to continuing to pursue clinical research that will potentially help better identify and manage neurological disorders, including brain injuries such as concussion."

BA combines non-invasive, multi-channel EEG technology with sophisticated signal processing and analysis algorithms to measure patterns of brain networks activated during specific brain processes and deliver both quantitative and qualitative insights into brain functionality.



The full publication of the independent research, conducted by researchers at the University of Pittsburgh Schools of the Health Sciences and the University of Pittsburgh Medical Center (UPMC), can be found at http://link.springer.com/article/10.1007/s11682-015-9412-6.

Study Design
This study was conducted among 37 athletes with a medically-diagnosed concussion with post-traumatic migraine (PTM) (n=15) and without (NO-PTM) (n= 22), as well as 20 individuals without concussion, between 14 - 29 years old. A repeated measures design was used to evaluate Brain Network Activation (BNA™), EEG-ERP, cognitive performance and symptoms at one-, two-, three- and four-week intervals. The BNA networks were evaluated during the performance of an auditory Go/NoGo task, which measures several brain processes, including attention, inhibition, motor response and reaction time.


About ElMindA Ltd. and BNA
Founded in 2006 to address an unmet need in the accurate, objective diagnosis and treatment of brain-related disorders, ElMindA is pioneering brain assessment technologies designed to inform critical decisions by providing a clear view of brain function over time. The company uses a data-driven approach to transform algorithmic science and neuroscience expertise into routine clinical practice, and is a preferred partner of industry-leading organizations based on the rigor of its science and technology development.

ElMindA has established a growing database of brain activity from both healthy subjects and patients with brain-related disorders. The database currently includes more than 10,000 BNA™ datasets, which provide a robust, clinically supported foundation to potentially help identify and manage neurological disorders such as ADHD or pain, and brain injuries such as concussion.

In 2014, BNA received U.S. Food and Drug Administration (FDA) clearance for use in 14- to 24- year-olds.

For more information, please visit www.elminda.com.


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